The role of sperm DNA fragmentation in infertility and miscarriages

BREAKS IN DNA STRANDS = NO GENETIC MATERIAL TRANSPORT

During cell division, DNA is transferred to each new cell just like a train transfers cargo to a destination. If a train’s tracks are damaged, the train cannot make it to the destination. The same is true when DNA strands are damaged. Both the train and the DNA are derailed.

If there are serious breaks in the DNA (genetic information is “broken”, “damaged”), new cells will be incomplete and unable to continue the cell division process. Embryonic development stops.

t is now known that male infertility goes hand-in-hand with damaged genetic material. More cells with damaged DNA means more damaged genetic material. More damaged genetic material means lower chances for successful pregnancy.

Also, a miscarriage may be associated with DNA sperm fragmentations. DNA fragmentations in spermatozoa could therefore be a possible explanation specifically for recurrent miscarriages.